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Syed Muhammad Kamran has a diverse work experience spanning several companies. Syed Muhammad began their career as an intern at Al Karam Textiles Mills Karachi in 2005. From there, they worked as a Textile Designer at Thredz Design House from 2005 to 2010. In 2010, they joined Indus Valley School of Art and Architecture as a Senior Lecturer, where they stayed until 2015. During their time at Indus Valley School, Kamran also took on a role as a Design Consultant at Bonanza Garment Industries from 2011 to 2014. In 2015, they joined Khaadi as a Senior Manager of Product Development and later became an Innovator in Textile Design Excellence.

Syed Muhammad Kamran attended the Indus Valley School of Art and Architecture from 2002 to 2005, where they obtained their Bachelor's Degree in Textile Design. Prior to that, from 2000 to 2001, they studied Pre Engineering at Govt Degree College Malir Cantt.