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Karim has developed novel X-ray imaging devices and systems since 1998. He has supported two start-ups (Ignis Innovation and Ultrascan) and founded two companies (ActivPixel and KA Imaging) in the past two decades. He has raised more than $15M in research grant funding, trained over 40 PhD and MASc students, has co-authored 250+ publications and 50+ patents. Some of the X-ray circuit technology he developed is now used in ultrasonic fingerprint sensors in mobile phones and tablets.