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Katie Pollard and her team develop statistical and computational methods to compare genomes and use the differences to decode how genomes work. Their analyses of massive sets of genomic and epigenomic data include investigating human genetic variation, understanding what makes humans unique compared to other species, and characterizing the genomic diversity of the human microbiome, the group of bacteria that populate the digestive system and other body sites. This evolutionary focus, coupled with rigorous statistical methods and bioinformatics tool development, gives the lab a unique perspective on human health and disease.