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Lufei Hu has extensive work experience in the field of pharmaceutical research. Starting in 1994, they worked at the Joan & Sanford I. Weill Medical College of Cornell University as a Postdoctoral Associate and later as an Assistant Professor until 2003. They then joined Boehringer Ingelheim as a Senior Scientist from 2003 to 2008. After that, they worked at Gilead Sciences as a Research Scientist II from 2009 to 2017. From 2017 to 2021, they worked as an Associate Principal Scientist at Merck. Currently, Lufei Hu holds the position of Director, In Vivo Pharmacology at iBio, Inc. as of September 2021.

Lufei Hu obtained a B.S. degree in Physiology from Nanjing University in 1985. Following that, they pursued an M.S. degree in Cardiology at Nanjing Medical University between 1985 and 1989. Lufei then attended the University of Mississippi Medical Center, where they completed their Ph.D. in Physiology from 1989 to 1994. Later on, they pursued an MBA at City College of New York from 2000 to 2002.