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Annette Rubin has held a variety of roles in the corporate world since 1997. Annette began their career as an Assistant Buyer at Famous Barr in 1997, followed by an Account Executive role at Estee Lauder in 1998. In 2001, they founded Belli and co-authored Belli Beautiful. From 2009 to 2012, they held the roles of President Belli and VP Consumer Product Division at ABT-Advanced Biotech. During this same time period, they were also a Board Member and Marketing Chair at Seraph Capital. In 2012, they became Managing Partner and COO at Premier HealthSource, and in 2015 they were appointed CEO of HydroPeptide LLC.

Annette Rubin attended Southern Illinois University Edwardsville, where they studied Anthropology.