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Mike Smith has had experience working in two different companies. From March 2014 to November 2014, they served as a Team Leader at Picsolve International Ltd. In June 2015, they joined Health iQ Ltd as a Business Development Manager, where they were responsible for marketing the company's products and services, developing and implementing revenue growth strategies, and pitching their offerings. Mike later became an Account Manager in June 2016, where they focused on developing solutions using real-world data, using discrete event simulation to model patient pathways, and implementing marketing strategies. In January 2019, they were promoted to Senior Account Manager, and in October 2019, they assumed the position of RWE Solutions Director.

Mike Smith obtained their Bachelor's Degree in Mathematics from Kingston University, where they studied from 2012 to 2015.