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Jonathan Guice has a diverse work experience starting in 2012 as an EKG/Telemetry Tech at Florida Hospital Tampa, where they performed EKG's, operated chest compressions during Code Blues, and maintained communication with healthcare professionals. Jonathan then worked at Tampa General Hospital as a Cardiac Monitor Tech for a few months in 2013. From there, they joined Laser Spine Institute in 2013 as a Patient Coordinator, and later became a Physician Relations Consultant, developing relationships with referring physicians and educating potential patients and physicians about LSI until 2018. Finally, they became the Director of Marketing at Florida Eye Specialists & Cataract Institute in 2018.

Jonathan Guice earned a Bachelor of Science (B.S.) degree in Biomedical Sciences from the University of South Florida, where they studied from 2007 to 2011.