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Dr. Jaffe is the Robert Machemer Professor of Ophthalmology and a member of the vitreoretinal faculty at Duke University Eye Center. He is chief of the Retina Division, and founded and directs the Duke Reading Center. Dr. Jaffe received his medical degree and his ophthalmology residency training at the University of California, San Francisco. He completed a two-year combined clinical and research vitreoretinal fellowship at the Medical College of Wisconsin. He joined the faculty at Duke University in 1989.

He has published over 320 articles in peer-reviewed journals and has an active clinical and basic science research program. Dr. Jaffe treats patients with a variety of medical and surgical vitreoretinal and uveitis diseases. His clinical research interests include the use of optical coherence tomography and artificial intelligence in clinical retinal treatment trials, novel medical and surgical therapies of uveitis and other posterior segment disorders. He has been a pioneer in the development of sustained drug delivery systems to treat ocular disease. He has participated in numerous clinical trials of new therapies for uveitis and vitreoretinal diseases. He directs a basic research program to investigate the mechanisms responsible for macular degeneration.

Dr. Jaffe serves on the Editorial Board of the journals Retina, Current Opinions in Ophthalmology, and Ocular Surgery News and reviews manuscripts for a variety of clinical and investigative ophthalmology journals.