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Shien Guo has extensive work experience in the field of clinical outcome assessment, modeling and simulation, and research in the pharmaceutical industry. They worked at Evidera since 2013, holding various roles including Vice President of Science, Senior Research Scientist, General Manager/Senior Research Leader, and Senior Director/Senior Research Scientist. Prior to Evidera, they worked at United BioSource Corporation as a Research Scientist and Senior Research Associate.

From 1997 to 2005, Shien Guo attended Saint Louis University. It is not specified whether they obtained a degree or their field of study during this time period.