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Brianna MacDonald has a varied work experience spanning several industries. Brianna most recently worked as a Senior Accountant at Evelo Biosciences starting in February 2022. Prior to that, they held the role of Staff Accountant at Sage Therapeutics from January 2018 to February 2020, where they were involved in software implementations, cash management, and fixed asset reconciliation. Before Sage Therapeutics, Brianna worked as a Staff Accountant at Teknor Apex Company from June 2017 to January 2018, and as a Staff Accountant at The Greysmith Companies from May 2016 to June 2017. Brianna also has experience as a Senior Accountant and Manager of Joint Ventures at LINEAR TITLE & SETTLEMENT SERVICES, LLC from February 2015 to May 2016. Additionally, Brianna has worked as a Bartender at Ritrovo Italian Pub and Grille from an unknown start date to May 2016. Brianna began their accounting career as a Staff Accountant at Linear Title & Closing in August 2012, where they worked until February 2015. Brianna's earliest work experience was as an Intern at the Volunteer Income Tax Assistance Program from January 2010 to April 2010.

Brianna MacDonald attended the University of Rhode Island - College of Business from 2007 to 2011, where they earned a Bachelor of Science (BS) degree in Accounting. At some point, they also pursued a Bachelor of Science (B.S.) degree in Accounting from the same institution. The specific start and end years for this second degree are not provided.