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Tigabu Melkamu has worked as a Pharmacy Head at the Ethiopian Red Cross Society. Tigabu also has experience as a Pharmaceuticals Distribution Management Officer and a Warehousing & Inventory Management Officer at EPSA-Ethiopian Pharmaceuticals Supply Agency.

Tigabu Melkamu attended the University of Gondar from 2015 to 2019, where they obtained a degree in Pharmacy (B.PHARM). Prior to this, from 2013 to 2018, they also studied at the University of Gondar and earned a Bachelor's degree in Pharmacy.