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Federoff is a professor of neurology at the University of California, Irvine, and the former CEO of UCI Health. Prior to his time at UCI Health, Federoff served as executive vice president of Health Sciences and executive dean at Georgetown University. He has published over 275 peer-reviewed and invited articles. In addition to his scholarly work, Dr. Federoff has also cofounded neurologic disease-focused MedGenesis Therapeutix and Brain Neurotherapy Bio.