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Melissa Breen has worked in the healthcare industry for over 12 years. In 2020, they began working as a Partnership Success Manager for Engooden Health. Melissa also held the position of Client Account Specialist at the same company. Additionally, they worked as a Patient Care Navigator, coordinating the needs of chronically ill patients and working with supporting clinicians to help them operate as efficiently as possible. Prior to this, they worked as a Patient Service Representative at Prisma Health in 2019, a Clinical Office Coordinator at Emerson Hospital in 2017, a Front End Assistant Manager at Market Basket in 2008, and a Continuing Medical Education Assistant at Lowell General Hospital in 2015. In 2017, they also worked as a Student Intern at Lowell General Hospital Center for Community Health & Wellness, where they collaborated with the Merrimack Valley Food Bank to help organize Lowell General Hospital's annual food drive, wrote monthly articles on different topics, attended staff meetings and community meetings, participated in community health fairs, presented monthly education tables, and created and implemented lesson plans.

Melissa Breen attended the University of Massachusetts Lowell from 2012 to 2017, studying Public Health.