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Madichaba Ledwaba began their work experience in 2020 at Triton Pharmaceuticals as a New Product Development Technical Assistant. In this role, they gained valuable knowledge in creating manufacturing and packing documents, as well as updating documents and handling deviations. Madichaba also learned about various manufacturing and packing processes in a pharmaceutical plant. Madichaba continued their work at Triton Pharmaceuticals as a Document Creator/Controller until 2021.

In 2022, they joined EMGuidance as a Medicine Content Assistant.

Madichaba Ledwaba obtained a Bachelor's degree in Biochemistry from the University of Pretoria/Universiteit van Pretoria. Madichaba attended the university from 2013 to 2019.