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Girija Phadke has a diverse work experience in the medical field. Girija began working at East Boston Neighborhood Health Center in 2017, starting as a Physician and eventually becoming the Medical Director in April 2022. Prior to that, they worked as a Resident Physician at Saint Peter's University Hospital from 2015 to 2017. Girija also served as a PGY 1 at Upstate Medical University from 2014 to 2015. Additionally, they gained research experience as a Research Volunteer at Tufts Medical Center in 2013. Girija's career started with an internship at Sassoon General Hospitals in Pune, where they worked from 2011 to 2012.

Girija Phadke attended B. J. Medical College from 2006 to 2012, where they obtained a Bachelor of Medicine, Bachelor of Surgery (MBBS) degree. In 2012, they were a visiting student at the Icahn School of Medicine at Mount Sinai.