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Hannah De Simone has a diverse work experience spanning over 17 years. Hannah started their career as a Grants Processing Manager at JCF in 2004 and then transitioned to a Grants Operation Manager role at JCC in Manhattan in 2006. In 2008, they worked as a Social Work Intern at the Food Bank For New York City before becoming a Social Work Intern at CAUSE-NY in 2009. Hannah then joined Educational Alliance as a Social Worker in 2010. Their most recent and current role is at DKMS US, where they have held several positions since 2013, including Workup Coordinator, Manager of Medical Logistics and Clinical Data, Manager of Workup and Medical Logistics/Clinical Data, and currently serves as the Head of Department for Workup, Clinical Data, and Medical Logistics.

Hannah De Simone earned a Master of Social Work (MSW) degree from Hunter College, where they studied social work, from 2008 to 2010. Prior to that, they obtained a Bachelor of Arts (BA) degree in Government and International Relations from Clark University, where they studied from 2000 to 2004.