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Clayton is the Chief Technology Officer at Dimagi. Since 2006, Clayton has led engineering initiatives in designing and developing ICT systems that improve service delivery at the last mile. At Dimagi, Clayton leads the technical development of CommCare, the world's largest digital health platform. His research has focused primarily on developing clinical protocols for low-resource settings as well as applying human-centered interaction practices to build software systems for the last mile.

Prior to Dimagi, Clayton worked as a developer at the Advanced Materials Laboratory division of Sandia National Labs. He has served as a Visiting Lecturer for the User Interface Design and Implementation course within the Department of Computer Science at the Massachusetts Institute of Technology (MIT). Clayton holds a B.S. and a Masters in Engineering in Computer Science and Engineering from MIT.