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Dr. Penn is a cardiologist and director of research of the cardiovascular medicine fellowship at the Summa Cardiovascular Institute. He also serves as professor of medicine and integrative medical sciences at Northeast Ohio Medical University, where he leads the Skirball Laboratory for Cardiovascular Cellular Therapeutics. Previously, Dr. Penn was a cardiologist at the Cleveland Clinic, where he served as the director of the Coronary Intensive Care Unit, director of the Experimental Animal Laboratory, director of the Bakken Heart-Brain Institute and the founding director of the Center for Cardiovascular Cell Therapy.

Dr. Penn completed his undergraduate and postgraduate work at Case Western Reserve University completing a Ph.D. in biomedical engineering in 1989 and earning his M.D. in 1994. He is board certified in internal medicine and cardiovascular medicine.