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Karen Harrison Dening has a diverse work experience. Karen worked at Dementia UK as the Head of Research & Publications and Director of Admiral Nursing starting from October 2010. Karen joined The University of Nottingham in February 2013 as an Honorary Lecturer. In the same year, they also became an Honorary Associate Professor at the Institute of Mental Health, University of Nottingham. Before that, they were a Steering Group Member at the RCN Older Peoples Forum from October 2010 to October 2015. Prior to that, they served as a Senior Nurse in OPMH at Leicestershire Partnership NHS Trust from 2000 to 2007.

Karen Harrison Dening received their education in the field of end-of-life care and dementia. In 2001, they obtained a Master of Arts in Nursing from De Montfort University in Leicester, specializing in end-of-life care in dementia and advance care planning. Karen pursued further studies at UCL, completing their Doctor of Philosophy (PhD) in End of Life Care in 2014. Additionally, while at UCL, they worked on another PhD, this time focusing on advance care planning in dementia, with the start year mentioned as 2008. The end year for their second PhD is not specified.