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Karen Kramer began their work experience in 1993 at Stein & Company, now known as Mesirow Financial, where they served as a Human Resources professional. Karen held this role from November 1993 until February 1996. In 1996, they joined Association Management Center as the Vice President of Human Relations, and the duration of their tenure in this role is not specified.

Karen Kramer obtained a Bachelor's degree in Legal and Business Administration, with a major in Paralegal studies, from Mallinckrodt College/Loyola University. Karen pursued further education and received their MBA from the Quinlan School of Business, Loyola University Chicago, specializing in Business.