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Mackenzie (Knopf) Blake has a diverse work experience. Mackenzie began their career as a Hostess at Houlihan's Restaurants, Inc. in 2014 and worked there until 2017. In 2017, they joined ALICES RAINBOW CHILDCARE CENTER INC as a Teachers Aide, where they worked until 2018. During the same year, they also worked as a Physical Therapy Intern at Athletico from January to August. In 2018, Mackenzie joined Marianjoy Rehabilitation Hospital as a Therapy Support Technician and worked there until 2020. From 2020 to 2021, they worked at Northwestern Medicine as a Patient Service Representative and then transitioned to the role of Oncology Navigator from 2021 to 2022. Currently, Mackenzie is working as the Lead Patient Advocate at Compass Health Center starting from May 2022.

Mackenzie (Knopf) Blake, MHA earned a Master's degree in Health/Health Care Administration/Management from Capella University from 2019 to 2022. Prior to that, they obtained a degree in Health and Human Physiology with a focus on Kinesiology and Exercise Science from the University of Iowa, completing their studies from 2015 to 2018. Mackenzie also received multiple certifications, including being on the President's List at Capella University for various semesters between 2020 and 2022.