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Madhu Subbu has a diverse work experience in various companies and roles. In 2005, Madhu started their career as a Solutions Engineer at Oracle, where they worked until 2008. From 2008 to 2009, Madhu served as a Research Assistant at Carnegie Mellon University. In 2010, they joined Credit Suisse as an Applications Architect and later transitioned to the role of Engineering Lead in Collateral Optimization, which they held until 2018. During this time, Madhu also worked on scalability and asset management as an Engineering Lead at JPMorgan Chase & Co. From 2019 to 2021, Madhu worked at Chainalysis Inc. as an Engineering Lead in Investigations. In 2019, they also became the Chief Executive Officer at Enigmatch Inc. Currently, Madhu is the Managing Director and Head of Securities Finance Technology at Clear Street, starting in October 2021.

Madhu Subbu completed their Bachelor of Engineering (BE) in Computer Science & Engineering from Anna University in 2005. Following that, they pursued a Masters degree in Information Science at Carnegie Mellon University from 2008 to 2009.