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Matt Clarke has been in the consulting industry since 1995. Matt began their career as a Consultant at Tularik, Inc. (now Amgen Inc.). In 1997, they became the CEO of Clarke Consulting and also took on Consultant roles at Sunesis Pharmaceuticals, Theravance, Metabolex, and Amarin Corporation. In 2002, they became a Consultant at Five Prime Therapeutics. Matt also held Consultant roles at Cellerant Therapeutics in 2005, Nuvelo in 2006, and Predicant Biosciences in 2004.

Matt Clarke graduated from Stanford University in 1995 with a Bachelor of Science in Symbolic Systems, which they earned between 1991 and 1995.