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Alex DeSanctis has over 15 years of experience in the advertising industry. Alex began their career in 2005 as an Account Executive at Metro US. In 2007, they moved to Bonnier Corporation as an Account Manager. In 2008, they joined Time Inc. as Vice President, Head of Industry - Global Advertising Solutions, VP, Associate Publisher, and National Advertising Director, Integrated Sales. In 2015, they moved to Rodale Inc. as National Advertising Director, Integrated Sales. In 2019, they became the Global Vice President, Audience Solutions at PubMatic. Most recently, in 2021, they joined CivicScience and Rulo (a CivicScience company) as GM, Advertising Solutions.

Alex DeSanctis has attended two educational institutions: New York University and State University of New York at Delhi. The exact degree and field of study are unknown.