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Elizabeth Horn has held a number of positions in their career. Elizabeth began their professional journey in 1981 as the Director of Marketing and Communications at Boole & Babbage. In 1984, they became the President of Horn Productions Inc. In 2007, they Co-Founded Medical Mine Incorporated. From 2008 to 2016, they served as the Chief Marketing Officer at ChARM Health. In 2019, they became the Co-Founder of The BRAIN Foundation and Founding Partner of Autism Impact Fund. Currently, they are the Executive Director of 2m Foundation.

Elizabeth Horn attended Miami University, where they earned a Bachelor of Arts in English.