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Shamssi Khademe has a diverse work experience in the healthcare industry. Shamssi started their career as a Staff Registered Nurse at a hospital, specializing in the Burning unit, ICU, NICU, and Pediatric Unit. Shamssi worked in this role for 12 years before moving on to become a Personal Support Worker (PSW) at AGTA Home Health Care. After two years, they transitioned to UHC, where they continued working as a PSW for another year. Shamssi then joined VMG & EYMC as a Physician Assistant & Phlebotomist, serving in that role for three years. Following that, they worked as a Clinical Research Nurse at LMC Manna Research for an undisclosed period of time before moving on to their current role at Biopharma Service inc. (CRO) as a Clinical Research Nurse.

Shamssi Khademe attended George Brown College from 2014 to 2016, where they completed an Academic Pathway for IEN (International Educated Nurse). They also attended Saint Francis Xavier (SFX) Sixth Form College, but no specific details about their degree or field of study at this institution are provided.