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Jay Lillquist started their work experience in 1990 at Pfizer as a Senior Scientist, where they worked until 2009. In 2016, they joined Kolltan Pharmaceuticals, Inc. as a Scientist for a brief period from August to October. Later in the same year, they moved to Celldex Therapeutics as a Scientist III, where they are currently employed.

Jay Lillquist obtained a Master of Science (MS) degree in Genetics from Florida State University. The exact start and end dates of this education are not specified.