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Alessandra Comandè has a diverse work experience including roles as a Validation Engineer at CAI starting in April 2023, a QC lab analyst at Philip Morris International from April 2022 to March 2023, and a High School Teacher at IIS F. Albert from October 2020 to August 2021. Alessandra also worked as a Researcher in drug delivery systems at the University of Calabria from November 2019 to May 2020 and as a PhD student in Translational Medicine, with a mention of "Doctor Europaeus," focusing on Molecular Design from November 2016 to April 2020. Additionally, they served as an Academic Tutor of Organic Chemistry at the University of Calabria from February 2017 to December 2018. Alessandra worked as a Visiting PhD Student and Researcher in the field of radiopharmaceuticals at King's College London from January 2019 to July 2019. Earlier in their career, they were a Research Laboratory Technician at NanoSiliCal Devices Srl from February 2016 to October 2016.

Alessandra Comandè has a Master's Degree in Pharmaceutical Chemistry and Technology from the University of Calabria, which was completed in 2015. Alessandra also achieved an English Certificate from IELTS ACADEMIC in 2018. Furthermore, Alessandra has pursued a Doctor of Philosophy - PhD from Università della Calabria, though the start and end years for this degree are not specified.