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Upendra Argikar began their work experience in 2006 at Novartis, where they held various roles including Investigator, Senior Investigator, Group Leader, and Section Head. Upendra worked at Novartis until 2021. In 2013, they also became an Editorial Board Member for Drug Metabolism and Disposition. In the following years, they took on the role of Editorial Board Member for Drug Metabolism Letters (2016), Xenobiotica (2016), and Current Drug Metabolism (2017). Currently, they are working as the DMPK Leader at the Bill & Melinda Gates Medical Research Institute.

Upendra Argikar has a Doctor of Philosophy degree in Medicinal Chemistry from the University of Minnesota. Additionally, they have a Bachelor of Pharmacy degree in Pharmaceutical Sciences from the University of Mumbai. No specific start or end years are provided for either of these educational experiences.