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Régine Mukania Mayele has worked in a variety of roles since 2014. Régine began their career as an Ambassador EF for EF Education First in 2014. In 2018, they were a Stagiaire Community Manager for Ethno tendance fashion week brussel. In 2021, they became a Junior Campaign Manager for BeInfluence Europe, and a Community Manager for Glacé Studio.

Régine Mukania Mayele attended Institut des Soeurs de Notre-Dame from 2009 to 2016, where they obtained a CESS degree. Régine then attended EF International Language Campuses from 2013 to 2017, studying English. Régine is currently attending IHECS from 2018 to 2024 to pursue a degree in Communication.