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Blanca Lesmes is the co-founder and CEO of TeleScan, a company they started in 2005. In the same year, they also co-founded BB Imaging and held the position of co-founder and principal. BB Imaging focuses on providing excellent care to ultrasound patients and developing innovative prenatal care solutions for rural markets. Blanca Lesmes joined ConfirmX Technologies in 2017 as the Chief Operating Officer, a position they held until 2018.

Blanca Lesmes obtained a Bachelor of Arts degree in International Business and Spanish from St. Edward's University between 1993 and 1997. Blanca later pursued an MBA degree in Business Administration and Management from the Texas McCombs School of Business, completing it from 2009 to 2011.