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Jamie Sklar Irizarry began their professional career in 2002 at the Children's Hospital of Philadelphia, where they held five different roles, including Nursing Informaticist, Senior Improvement Advisor for the Center for Healthcare Quality and Analytics, Improvement Advisor for the Office of Clinical Quality Improvement, Medication Safety Nurse, and Pediatric Intensive Care Unit. In 2016, they Co-Founded and became a Clinical Advisor at Bainbridge Health.

Jamie Sklar Irizarry obtained a Bachelor of Science in Nursing from the University of Pittsburgh in 2002, majoring in Registered Nursing/Registered Nurse. Jamie then went on to obtain a Masters of Science from the Philadelphia College of Osteopathic Medicine in Forensic Medicine. In October 2020, Jamie obtained a Cogito certification from Epic.