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Orlando Merced-O'Neill has extensive work experience in the healthcare industry. Orlando started their career as a Clinical Recovery Specialist at the University of Florida Tissue Bank in 1992 and worked there until 2000. Orlando then joined the University of Alabama Health Services Foundation as an Organ Recovery Specialist from 2001 to 2002. Orlando became a Surgical Recovery Specialist at Regeneration Technologies from 2002 to 2006. Orlando then joined AxoGen in 2006 and held the position of Manager of Tissue and Medical Services until 2011. In the same year, they also worked as an Associate Director QA at Bone Bank Allografts for a short period. From 2011 onwards, Orlando has been associated with AxoGen, where they have held multiple roles including Manager of Medical and Professional Services, Associate Director of Medical Services/Microsurgery Instructor, Principle & Microsurgery Instructor, and currently serves as the Director of Microsurgical Education.

Orlando Merced-O'Neill attended the University of Florida from 1987 to 1991, but did not specify a degree or field of study. Later, from 1997 to 1999, they obtained an Associate Science Degree in Nursing from Santa Fe College, specializing in Nursing Science. In 2017 and 2018, Orlando pursued certificate programs at Cornell University, earning a High-Performance Leadership Certificate in 2017 and an Executive Leadership Certificate in 2018.