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Calum MacRae has a diverse and extensive work experience in the medical and scientific field. Calum began their career in 1996 as an Internal Medicine Resident at Brigham and Women's Hospital. Calum then pursued a Cardiology Fellowship and worked as a Postdoctoral Fellow in the Fishman Laboratory at Massachusetts General Hospital.

In 2002, MacRae joined Harvard Medical School as a Professor and became a Principal Faculty Member at the Harvard Stem Cell Institute in 2009. Calum held multiple roles at Brigham and Women's Hospital, including Chief of Cardiovascular Medicine, Vice Chair for Scientific Innovation in the Department of Medicine, and Physician-Scientist.

MacRae is also involved in innovative projects and organizations. Calum served as the Director of One Brave Idea and the Principal Investigator for the Apple Heart and Movement Study. Additionally, they co-founded Atman Health and is currently an Advisor at gWell.

Throughout their career, MacRae has made significant contributions to the field of cardiovascular medicine and genetics through research, clinical work, and leadership positions.

Calum MacRae began their education in 1979 at The University of Edinburgh, where they pursued a degree in Experimental Physiology and completed their B.Sc. (Hons) in 1983. Calum continued their education at the same institution, and from 1979 to 1985, they studied Medicine and earned an MB, ChB degree. After a brief break, in 1991, MacRae enrolled in the University of London for their Ph.D. in Human Molecular Genetics, completing it in 1996.