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Michael O'Brien began their work experience as an Investment Banking Analyst at Guggenheim Partners in July 2016, where they worked until June 2018. In July 2018, they joined Athyrium Capital Management, LP as an Associate/Senior Associate, and later became a Vice President in July 2022.

Michael O'Brien has a Bachelor of Science in Economics with a focus on Finance and Accounting from The Wharton School, where they graduated Summa Cum Laude. Prior to that, they attended Concord-Carlisle Regional High School.