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Irene Susmano has a rich and varied work experience, with their most recent role being Co-Founding Partner and CIO at Arc Ventures since January 2014. Prior to this, they worked as the Chief Investment Officer at The Arc Companies since 1997. Irene also served as Vice President at Banco Itau Europa from 1996 to 1997. Irene's earliest known role was as a Vice President at Citibank, where they worked from 1987 to 1996.

Irene Susmano pursued their education with a strong focus on international business and finance, as well as Latin American studies. From 1986 to 1988, they attended Columbia | SIPA, where they obtained a Master of International Affairs (MIA) degree. During this time, they specialized in the field of International Business & Finance, along with Latin American studies. Irene further expanded their knowledge in the art world by enrolling at Christie's Education from 1995 to 1996. Although the information does not mention a specific degree earned, their studies concentrated on Modern & Contemporary Art. Prior to these postgraduate studies, Irene earned a Bachelor of Arts (BA) degree in Economics from Northwestern University, where they studied from 1980 to 1984.