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From 1995 to 2009, Jay Strum worked at GlaxoSmithKline as a Director. In 2009, they joined G1 Therapeutics as the Chief Scientific Officer and held that position until 2020. In 2020, they joined Incyclix Bio as the Chief Scientific Officer, a position they still hold.

Jay Strum earned a Bachelor of Science/Arts degree in Biology and Chemistry from Western Carolina University, which they attended from 1982 to 1987. Following this, Jay pursued a PhD in Biochemistry at Wake Forest University from 1987 to 1993.