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Gianluca Ruffi began their work experience in 1994 as an Endoscopy product specialist at Smith & Nephew. Gianluca then joined GE in 1999 as a Project Manager before returning to Smith & Nephew in 2001. At Smith & Nephew, they held various roles, including Sales & Market Manager, South European Marketing Director, and Global shoulder team leader. In 2015, Gianluca became the Strategic Marketing Director & Market Access, Italy, and later served as the Sales Excellence Director. Gianluca also held the position of Sales and Marketing Manager at Helca srl in 2019. Currently, Gianluca is the Sales Director Italy at Anika since October 2021.

Gianluca Ruffi has a Laurea in Ingegneria Elettronica with a specialization in Biomedica from Università di Pisa. Additionally, they have pursued further education at MIP Politecnico di Milano, where they completed a PEGASO Master in Percorso Gestione aziendale e sviluppo organizzativo. The duration and specific years of their education at both institutions are not provided.