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Brian Jacob has worked in various roles and positions throughout their career. In 2005, they served as a Hernia Surgeon at nychernia.com and also became the Director of Baricenter at the Laparoscopic Surgical Center of New York. Brian then held a position as an Associate Clinical Professor of Surgery at Mount Sinai Medical Center. In 2012, they founded inclinx.com, and in 2013, they created the International Hernia Collaboration, a closed and vetted Facebook group focused on optimizing patient outcomes and improving healthcare quality. Finally, in 2014, they became the Regional Medical Director at angelMD.

Brian Jacob attended the University of Michigan, but the specific start and end years, degree name, and field of study are unknown.