Dr. Richesson is a recognized expert in informatics and has developed applications and policies for the use of data standards and informatics in clinical research, particularly in rare diseases. She has conducted original research evidenced by numerous publications, presentations, and invited talks. She edited Clinical Research Informatics (Springer, 2012). She also co-leads the Phenotyping, Data Standards, and Data Quality Core for the NIH Health Care Systems Research Collaboratory, a demonstration program for the transformation of clinical trials based upon use of EHRs and healthcare systems partnerships. In this role, she is developing standard approaches and guidance for EHR phenotyping to support research and learning healthcare systems. She is also the co-lead of the Rare Diseases Task Force for the national distributed Patient Centered Outcomes Research Network (PCORNet), specifically promoting standardized computable phenotypes for rare diseases and helping to develop a national research infrastructure that can support observational and interventional research.