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Brandon Smith has a diverse work experience in the field of genetics. Brandon began their career as a Student at Cincinnati Children's Hospital Medical Center from September 2011 to April 2013. Following that, they worked as a Genetic Counselor at OhioHealth from June 2013 to June 2014. Since then, they have been associated with Ambry Genetics, starting as an Oncology Genetic Specialist from June 2014 to April 2016. Brandon then served as a Senior Genetic Specialist from April 2016 to April 2018. Subsequently, Brandon worked as a Manager, Genetic Specialists from April 2018 to November 2019 and as a National Account Director from November 2019 to October 2022. Currently, they hold the position of Business Development Director at Ambry Genetics starting from October 2022.

Brandon Smith completed a Bachelor of Science (BS) degree in Molecular Genetics and a Bachelor of Science (BS) degree in Psychology from The Ohio State University from 2006 to 2011. Brandon then pursued a Master of Science (MS) degree in Genetic Counseling/Counselor from the University of Cincinnati College of Medicine from 2011 to 2013.