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Karen Barber has a diverse work experience. Karen began working at the Muscular Dystrophy Association in 1991 as a Grants Manager, where they administered various aspects of the Basic Research Grant programs. Their responsibilities included processing applications, conducting annual review meetings, and overseeing grantee expenditures and progress. In August 2019, they were promoted to the role of Director of Grant Management at the same company. In December 2019, they joined Altum, Inc. as a Client Support Analyst. Altum is a leading provider of cloud software for research grants management. Karen's current role involves providing support to clients using their flagship product, ProposalCentral, and utilizing analytical tools such as Altum Insights and Altum Analytics.

Karen Barber attended Sahuaro High School from 1980 to 1983, where they obtained their high school diploma. Their field of study during this time is not specified.