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Marc Guillet has a diverse work experience spanning multiple industries. In 1991, they started their career as a Rehab director at UCLA and later served as the Director of Rehabilitation at the Stanford Athletic Department from 1997 to 2000. In 2002, they founded Agile Physical Therapy and served as the CEO/Founder. In 2006, they founded Excel Sports Medicine and held the position of CEO/Founder until December 2017. In the same year, they also joined PAMF as a Director and became the Executive Director of A Foundation Building Strength in 2008. Currently, since June 2018, they have been involved with Apeiron.life LLC as a Founder/Advisor.

Marc Guillet earned a Master of Science degree in Physical Therapy from Columbia University Vagelos College of Physicians and Surgeons, where they studied from 1989 to 1991.