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Mary Beth Thomas has a diverse work experience spanning over two decades. Mary Beth began their career as an Assistant Director in the neuroprotection program at Cogent Neuroscience in 1998. In 2003, they joined Tranzyme Pharma as an Assistant Director in the Neurosensory department. Mary Beth then worked as a Technology Commercialization Counselor at the Small Business & Technology Development Center from 2005 to 2006. From 2007 to 2007, they served as the Director of Technology Commercialization at the Small Business and Technology Development Center - SBTDC. In 2008, they became the Senior Director of Centers of Innovation Operations at the NC Biotechnology Center, a position they held until 2009 when they were promoted to Vice President of Emerging Sector Development. Mary Beth'slast role at NC Biotechnology Center was Senior Vice President of Science and Business Development, which they have held since 2018.

Mary Beth Thomas received their Bachelor of Science degree in Biotechnology from the Rochester Institute of Technology from 1984 to 1989. Mary Beth then went on to pursue a Doctor of Philosophy (Ph.D.) in Developmental Biology at the University of Cincinnati from 1990 to 1996. The information does not provide any details regarding their education at NHS.