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Nikolaos Ipiotis has a wealth of experience in various roles within the field of information technology and data management. Nikolaos is currently serving as the Chief Information Officer at the Advanced Research Projects Agency for Health (ARPA-H), a position they started in December 2023. Prior to this, they held the role of Chief Data Officer at the U.S. Department of Health and Human Services (HHS) from September 2021 to December 2023. Nikolaos also worked as an Information Technology Project Manager at HHS from August 2020 to May 2022. Before their time at HHS, Nikolaos was a Service Area Manager at the NIH Center for Information Technology from April 2016 to May 2022. From December 2011 to April 2016, they served as the Branch Chief at the National Science Foundation (NSF). Lastly, Nikolaos started their career at Booz Allen Hamilton, where they worked as a Sr. Associate from June 1998 to December 2011.

From 1993 to 2000, Nikolaos Ipiotis attended George Mason University, during which time no degree or field of study was specified.