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Shirley Shapira's work experience includes working as the VP Clinical at 270Surgical since February 2017. Prior to that, they were a Co-Founder at Amplio starting in January 2015. From September 2015 to February 2017, they worked as a Clinical Research Consultant for various biotech companies. Shirley also held the position of VP Clinical at Motus GI Holdings, Inc. from October 2011 to August 2015. Earlier in their career, they worked as the Clinical Trials Director at MetaCure from April 2009 to August 2011 and as a Clinical Trials Manager at Stryker GI from January 2007 to February 2009.

Shirley Shapira completed their education in Israel at the Technion - Israel Institute of Technology. Shirley earned a Bachelor of Science degree in Biotechnology and Food Engineering from 1991 to 1995. Shirley then pursued a Master of Science degree in Biomedical Engineering from 1996 to 1998. Lastly, they obtained a Doctorate in Biomedical Engineering from the same institution from 1998 to 2002.