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Susan Guillen has a diverse work experience spanning over different industries. Susan began their career in 1996 as an Account Executive at FedEx, where they worked until 1999. Later, they worked as a Co-Founder at B's Purses from 2004 to 2008. In 2008, they worked as a Physician Liaison at American Sleep Medicine. From 2010 to 2012, they worked as an Account Executive at Twtelecom, followed by a role as Manager, Physician Services at American Family Care in 2012. During the same year, they joined American Sleep Medicine as an Administrator, where they were responsible for overseeing operations, marketing, and establishing successful partnerships. Susan held this position until 2016. Since 2016, Susan has been associated with Upstream Rehabilitation, initially working as a Regional Sales Manager and later as a Senior Regional Sales Manager. As of 2023, they hold the position of VP of Sales at the company.

Susan Guillen attended Memorial from 1984 to 1988. Susan then went on to Kent State University, where they obtained a Bachelor of Arts degree in Communications from 1989 to 1993.