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Wen-I Chang's work experience includes positions at various pharmaceutical companies. Starting in 1994, Chang worked as a Principle Scientist at Tanox, Inc. until 1998. In 2000, Chang joined Eli Lilly and Company as a Marketing Consultant until 2007. From 2007 to 2022, Chang worked at GSK, holding roles such as Global Commercial Director and Senior Director, Early Pipeline Commercial Strategy. Most recently, Chang is the Senior Vice President of Oncology Franchise Strategy at Transcenta, starting in April 2022.

Wen-I Chang has a Bachelor of Science degree in Genetic Engineering from Fudan University. Additionally, they hold a Master of Business Administration (M.B.A.) with a focus on Marketing and Finance from Columbia Business School. Wen-I also has a Doctor of Philosophy (Ph.D.) in Biochemistry and Cell Biology from Rice University.