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Professor McCluskey is Deputy Vice-Chancellor (Research) at The University of Melbourne and a Redmond Barry Distinguished Professor in Microbiology and Immunology.

He has published widely on the genetic control of specific immunity and his research has been recognized by a number of awards.

Professor McCluskey is a director of Australian Friends of Asha Slums, the Victorian Comprehensive Cancer Centre, UoM Commercial, Trinity College, the Chair of Nossal Institute Ltd, and a founding director of the governing board of the Atlantic Institute, Oxford. He is a consultant to the Australian Red Cross Blood Service Immunogenetics and Transplantation Services. He has previously been a board director of the Bionics Institute, the Florey Institute of Neuroscience and Mental Health, the Burnet Institute, and St Vincent’s Institute. Professor McCluskey led the development of the Peter Doherty Institute for Infection and Immunity, and also led the multi-institutional team that developed the Atlantic Fellows Social Equity Program supported by The Atlantic Philanthropies.