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Sameh Sayfo has a diverse work experience in the medical field. Sameh is currently the Program Director Endovascular Intervention Fellowship at The Heart Hospital Baylor Plano, a role they started in July 2023. Sameh is also a Clinical Assistant Professor at Texas A&M University School of Medicine since March 2023. Prior to these positions, they worked at Baylor Scott & White Health as an Interventional Cardiology and peripheral endovascular specialist and PERT Director starting from August 2015. Before that, they were an Interventional Cardiology fellow at Brown University from July 2014 to July 2015 and a Cardiology Fellow at the University of Louisville from July 2011 to July 2014. Sameh began their medical career as an Internal Medicine Resident at IUPUI in July 2008.

Sameh Sayfo attended Damascus University from 2000 to 2007 and obtained a degree in MD. From 2008 to 2011, they attended Indiana University–Purdue University Indianapolis for the Internal Medicine Residency Program. Following this, from 2011 to 2014, they studied at the University of Louisville for the Cardiovascular fellowship. In 2014, Sameh Sayfo also briefly attended Brown University for Interventional cardiology. They then pursued a Master of Business Administration (MBA) at the Naveen Jindal School of Management, UT Dallas from 2017 to 2020. Sameh Sayfo also holds a Master of Business Administration (MBA) from The University of Texas at Dallas, although the specific dates are unknown.